NEW: Shu Li, Zian Zhang, Wenjie Gu, Maël Gallas, David Jones, Pascal Boulet, Lindsay M. Johnson, Victoire de Margerie, Gavin Andrews, "Hot melt extruded High-Dose Amorphous Solid Dispersions containing Lumefantrine and Soluplus", International Journal of Pharmaceutics (2024)
NEW: Gallas M., De Margerie V. "Vertical Hot Melt Extrusion: A Cutting Edge Technology for Personalized and Sustainable Food Systems", Physical Science and Biophysics Journal (2024).
Ciardi D, Rigatelli B, Richaud E, Cloitre M, Tournilhac F: "Dual reconfigurable network from a semi‑crystalline functional polyolefin", Polymers (2024)
Gallas M, Boulet P & de Margerie V: “Extrusion for Pharma Applications: an Update”, SPE Polymers (2023).
Essa E, Amin M, Sultan A, Arafa M, El Maghraby G, McConville C: "Hot melt extrusion for enhanced dissolution and intestinal absorption of hydrochlorothiazide", Journal of Drug Delivery Science and Technology (2023).
Arieta M-P, Beltrán González F, Soledad Abarca de las Muelas S, Gaspar G, Sanchez Hernandez R, Ulagares de la Orden M, Martinez Urreaga J: "Development of tri-layer antioxidant packaging systems based on recycled PLA/sodium caseinate/recycled PLA reinforced with lignocellulosic nanoparticles extracted from yerba mate waste." eXPRESS Polymer Letters (2022).
De Margerie V, Mc Conville C, Dadou S, Boulet P, Aranda L, Walker A, Mohylyuk V, Jones D, Murray B & Andrews G, “Continuous manufacture of hydroxychloroquine sulfate drug products via hot melt extrusion technology to meet increased demand during a global pandemic: from bench to pilot scale”, International Journal of Pharmaceutics (2021).
Beltrán González F, Patricia Arrieta M, Moreno E,
Gaspar G: "Evaluation of the Technical Viability of Distributed Mechanical Recycling of PLA 3D Printing Wastes", Polymers (2021).
Kunchimon S, Tausif M, Goswami P, Cheung V: "Polyamide 6 and Thermoplastic Polyurethane Recycled Hybrid Fibres Via Twin-Screw Melt Extrusion", Journal of Polymer Research (2019).
De Margerie V & Maier H. “From Pharma Adapted Extrusion to Brand New Pharma Fitted Extrusion Design in Practical Guide to Hot Melt Extrusion” – Mohammed Maniruzzaman, Smither Rapra (2015).
Reference publications
We actively collaborate with companies, research institutes, universities, and non-profit organizations to advance our technology and innovations. This work often results in co-authored publications.
Rondol is also quoted in more than 150+ independent publications, written using Rondol's equipment.
You will find here some publications. Some of them can be directly downloaded here.
How does it work?
Hot melt extrusion (HME) is a solvent-free, continuous manufacturing process that mixes materials using heat and pressure, and forces the resulting homogeneous mixture into a uniform shape through a die. It is used in many industries where the smooth mixing of ingredients and precise application of heat are required; for example, pharmaceutical, food, cosmetics, plastics, materials science research and battery components.
Heating or cooling applied in 4-8 zones along the barrel
Die block, which squeezes material out in various shape profiles to be cut, wound, or processed.
1
Feeding the Ingredients: Raw materials, in the form of powders, pellets or liquids, are fed into the top of the extrusion machine.
2
Heating and Mixing: Inside the extruder, the materials are heated and melted while being mixed thoroughly by the turning motion of the twin screws. Our machines apply precise and user-defined quantities of heating at various points throughout the barrel.
3
Pressurizing and Shaping: The molten mixture is pushed (extruded) through a specially shaped opening (die), giving it a particular shape, like strands, sheets, or tubes.
4
Cutting or Processing: Materials can be extruded in specific shapes, or, once solid, can be cut or processed further into smaller pieces or specific products.
